New paper published in collaboration with Prof. Angela Scala (University of Messina)

New paper published in collaboration with Prof. Angela Scala (University of Messina)
New paper published in collaboration with Prof. Angela Scala (University of Messina)

A new paper entitled “Design of naturally inspired jellyfish-shaped cyclopolylactides to manage osteosarcoma cancer stem cells fate” has been recently published in Materials Science and Engineering: C.

We report the synthesis, characterization and biological profile of new bis-triazoled cyclo-(polylactide)s functionalized with folic acid (c-PLA-FA) or rhodamine (c-PLA-Rhod), obtained by an optimized combination of ROP and “click” chemistry reactions.  Salinomycin (Sal) was loaded into jellyfish-shaped c-PLA-FA and c-PLA-Rhod nanoparticles (NPs) by nanoprecipitation, with a good encapsulation efficiency and loading content. The biological studies focused on their antiproliferative effects on osteosarcoma bulk MG63 and cancer stem cells (CSCs). The cyclo-PLA-based nanoparticles killed CSCs and MG63, with a higher efficacy on CSCs; they (unloaded or Sal-loaded) evoked on CSCs a cellular response similar to the payload, with a higher effect than the free Sal. Internalization studies indicated a fast cellular uptake (within 2 h). To the best of our knowledge, this is the first study reporting anti-CSCs properties of cyclo-PLA with jellyfish architecture and we believe could contribute to the development of effective strategies for osteosarcoma targeting.

https://doi.org/10.1016/j.msec.2020.111291